Preparation of a Covalent Organic Framework TpBD-（NH<sub>2</sub>）<sub>2</sub>-<italic style="font-style: italic">D</italic>-（－）-<italic style="font-style: italic">α</italic>-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography

LAI Ya-lin; YU Zi-yun; QIN Gai-zhao; YUAN Li-ming

doi:10.19969/j.fxcsxb.22062106

您当前的位置：

首页 >

文章列表页 >

Preparation of a Covalent Organic Framework TpBD-（NH₂）₂-D-（－）-α-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography

Scientific Papers | 更新时间：2023-01-04

- Preparation of a Covalent Organic Framework TpBD-（NH₂）₂-D-（－）-α-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography
- Journal of Instrumental Analysis Vol. 41, Issue 12, Pages: 1800-1807(2022)
- 作者机构：
  
  云南师范大学化学化工学院，云南昆明 650500
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.22062106
  CLC：
扫描看全文
赖亚琳,禹紫云,秦该照等.共价有机框架材料TpBD-（NH₂）₂-D-（-）-α-苯甘氨酸用作高效液相色谱手性固定相的研究[J].分析测试学报,2022,41(12):1800-1807.

LAI Ya-lin,YU Zi-yun,QIN Gai-zhao,et al.Preparation of a Covalent Organic Framework TpBD-（NH₂）₂-D-（－）-α-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography[J].Journal of Instrumental Analysis,2022,41(12):1800-1807.
赖亚琳,禹紫云,秦该照等.共价有机框架材料TpBD-（NH₂）₂-D-（-）-α-苯甘氨酸用作高效液相色谱手性固定相的研究[J].分析测试学报,2022,41(12):1800-1807. DOI： 10.19969/j.fxcsxb.22062106.

LAI Ya-lin,YU Zi-yun,QIN Gai-zhao,et al.Preparation of a Covalent Organic Framework TpBD-（NH₂）₂-D-（－）-α-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography[J].Journal of Instrumental Analysis,2022,41(12):1800-1807. DOI： 10.19969/j.fxcsxb.22062106.

摘要

该文采用溶剂热法合成了一种共价有机框架材料（COFs）TpBD-（NO,2,）,2,，将TpBD-（NO,2,）,2,还原为TpBD-（NH,2,）,2,后用,D,-（－）-,α,-苯甘氨酸对其进行手性修饰得到手性COFs材料TpBD-（NH,2,）,2,-,D,-（－）-,α,-苯甘氨酸。对TpBD-（NO,2,）,2,、TpBD-（NH,2,）,2,及TpBD-（NH,2,）,2,-,D,-（－）-,α,-苯甘氨酸3种COFs材料进行表征，并采用“网包法”制备了TpBD-（NH,2,）,2,-,D,-（－）-,α,-苯甘氨酸手性固定相。为考察该固定相的分离性能，将其用于制备高效液相色谱（HPLC）手性柱，并使用正己烷－异丙醇（体积比9∶1）和甲醇－水（体积比9∶1）为流动相，实现了13种手性化合物和5种苯系位置异构体的分离。且该色谱柱具有较好的重现性。实验表明TpBD-（NH,2,）,2,-,D,-（－）-,α,-苯甘氨酸用作HPLC固定相用于手性物质和苯系位置异构体分离具有良好的研究意义。

Abstract

In this work，a covalent organic framework（COF） material TpBD-（NO,2,）,2, was firstly synthesized by solvothermal method，which was then reduced to TpBD-（NH,2,）,2,，and finally，a chiral COF material TpBD-（NH,2,）,2,-,D,-（－）-,α,-phenylglycine was obtained by chirally modifying the TpBD-（NH,2,）,2, with ,D,-（－）-,α,-phenylglycine．Three COF materials，i.e．TpBD-（NO,2,）,2,，TpBD-（NH,2,）,2, and TpBD-（NH,2,）,2,-,D,-（－）-,α,-phenylglycine were characterized，and a chiral stationary phase of TpBD-（NH,2,）,2,-,D,-（－）-α-phenylglycine was prepared by “net-wrap method”．In order to investigate the separation performance of the stationary phase，it was used to prepare a chiral column for high performance liquid chromatography（HPLC），,n,-hexane－isopropanol（9∶1，by volume） and methanol－water（9∶1，by volume） were used as mobile phases．13 chiral compounds and 5 benzene positional isomers were separated on this column with good reproducibility．The experiment showed that the separation effect of TpBD-（NH,2,）,2,-,D,-（－）-,α,-phenylglycine chromatographic column was excellent. It was of a certain research significance to use the chiral COF material TpBD-（NH,2,）,2,-,D,-（－）-,α,-phenylglycine as HPLC stationary phase for the separation of chiral substances and benzene isomers.

关键词

共价有机框架材料手性固定相高效液相色谱手性分离

Keywords

covalent organic framework materialschiral stationary phasehigh performance liquid chromatographychiral separation

references

Chen J，Peng H J，Zhang Z L，Zhang Z Y，Ni R X，Chen Y P，Chen P，Peng J D．Talanta，2021，233：122524.

Yang C Y，Wang Y F，Sun W W，Yang J R，Lu Z Y，Yuan L M．J. Instrum. Anal. （杨璨瑜，王一帆，孙维维，杨江蓉，路振宇，袁黎明．分析测试学报），2014，33（10）：1142－1147.

Shi X H，Luo J M，Yang D M，Fu Q M，Qiu Y H，Wu X O，Wang X W．J. Instrum. Anal. 石兴红，罗金梅，杨淡梅，符秋美，邱颖姮，邬晓鸥，王晓炜．分析测试学报），2022，41（3）：392－397.

Kou W T，Yang C X，Yan X P．J. Mater. Chem. A，2018，6（37）：17861－17866.

Geng K Y，He T，Liu R Y，Tan K T，Li Z P，Tao S S，Gong Y F，Jiang Q H，Jiang D L．Chem. Rev.，2020，120（16）：8814－8933.

Xiong W Q．Study on Chiral Covalent Organic Frameworks as Stationary Phases for High Performance Liquid Chromatography. Kunming：Yunnan Normal University（熊婉淇．手性共价有机骨架用于高效液相色谱固定相的研究．昆明：云南师范大学），2021.

Yu Y Y，Yuan B Y，Xu N Y，Zhang J H，Fu N，Xie S M，Yuan L M．J. Instrum. Anal. 余云艳，袁宝燕，许娜艳，章俊辉，富楠，谢生明，袁黎明．分析测试学报），2020，39（2）：167－173.

Li L，Fu S G，Yuan B Y，Xie S M，Yuan L M．J. Instrum. Anal. （李丽，付仕国，袁宝燕，谢生明，袁黎明．分析测试学报），2017，36（12）：1439－1444.

Guo P，Yuan B Y，Yu Y Y，Zhang J H，Wang B J，Xie S M，Yuan L M．Microchim. Acta，2021，188：292.

Xu N Y，Guo P，Chen J K，Zhang J H，Wang B J，Xie S M，Yuan L M．Talanta，2021，235：122754.

Yuan L M．Chiral Recognition Materials. 2nd ed. Beijing：Science Press（袁黎明．手性识别材料．2版．北京：科学出版社），2010：334－337.

Zhang S N，Zheng Y L，An H D，Aguila B，Yang C X，Dong Y Y，Xie W，Cheng P，Zhang Z J，Chen Y，Ma S Q．Angew. Chem. Int. Ed.，2018，57（51）：16754－16759.

Bhunia S，Deo K A，Gaharwar A K．Adv. Funct. Mater.，2020，30（27）：2002046.

Wang J C，Kan X，Shang J Y，Qiao H，Dong Y B．J. Am. Chem. Soc.，2020，142（40）：16915－16920.

Han X，Yuan C，Hou B，Liu L J，Li H Y，Liu Y，Cui Y．Chem. Soc. Rev.，2020，49（17）：6248－6272.

Han X，Huang J J，Yuan C，Liu Y，Cui Y．J. Am. Chem. Soc.，2018，140（3）：892－895.

Yuan C，Jia W Y，Yu Z Y，Li Y N，Zi M，Yuan L M，Cui Y．J. Am. Chem. Soc.，2022，144（2）：891－900.

Chong J H，Sauer M，Patrick B O，Maclachlan M J．Org. Lett.，2003，5（21）：3823－3826.

Chandra S，Kandambeth S，Biswal B P，Lukose B，Heine T，Banerjee R．J. Am. Chem. Soc.，2013，135（14）：5328－5331.

Lohse M S，Stassin T，Naudin G，Wuttke S，Ameloot R，Vos D D，Medina D D，Bein T．Chem. Mater.，2016，28（2）：626－631.

He Y J，Li K L，Li Q，Zhang P，Ai P，Yuan L M．Chin. J. Chromatogr. （何义娟，李克丽，李倩，张鹏，艾萍，袁黎明．色谱），2019，37（4）：383－391.

Wang Y，Chen J K，Xiong L X，Wang B J，Xie S M，Zhang J H，Yuan L M．Anal. Chem.，2022，94（12）：4961－4969.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Scientific PapersSeparation of Chiral Compounds Using Chiral Covalent Organic Frameworks CTpPa-1 as HPLC Stationary Phase

Separation of Chiral Compounds Using a Chiral Metal-Organic Framework ［Cu3(HL)2(L)2(bpy)3］·4H2O for High Performance Liquid Chromatography

Determination of Polycyclic Aromatic Hydrocarbons in Environmental Water by HPLC with Stir Bar Adsorption Extraction Based on Covalent Organic Framework Coating

Polydopamine Modified Titanium Dioxide Nano/Submicro Particles Coating for Solid Phase Microextraction of Phthalic Acid Esters

Related Author

No data

Related Institution

云南师范大学化学化工学院

School of Chemistry and Chemical Engineering，Lanzhou City University

Provincial Key Laboratory of Gansu Higher Education for City Environmental Pollution Control

Provincical Key Laboratory of Gansu Higher Education for City Environmental Pollution Control

College of Chemistry and Chemical Engineering，Qinghai Minzu University

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Preparation of a Covalent Organic Framework TpBD-（NH2）2-D-（－）-α-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography

DOI：10.19969/j.fxcsxb.22062106

摘要

Abstract

关键词

Keywords

references

Preparation of a Covalent Organic Framework TpBD-（NH₂）₂-D-（－）-α-phenylglycine and Its Application Used as Chiral Stationary Phase for High Performance Liquid Chromatography