Membrane Inlet Mass Spectrometry Techniques and Their Applications

WANG Wei-guo; HUANG Wei; RUAN Hui-wen; XU Chu-ting; YANG Jun-chao; LI Bin; LI Hai-yang

doi:10.19969/j.fxcsxb.21050702

您当前的位置：

首页 >

文章列表页 >

Membrane Inlet Mass Spectrometry Techniques and Their Applications

Reviews | 更新时间：2023-01-04

- Membrane Inlet Mass Spectrometry Techniques and Their Applications
- Journal of Instrumental Analysis Vol. 41, Issue 2, Pages: 283-289(2022)
- 作者机构：
  
  1.国民核生化国家重点实验室，北京 102205
  2.中国科学院大连化学物理研究所，中国科学院分离分析化学重点实验室，大连市在线谱学分析仪器重点实验室，辽宁大连 116023
  3.云南警官学院，云南昆明 650223
- 作者简介：
- 基金信息：
- DOI：10.19969/j.fxcsxb.21050702
  CLC：
扫描看全文
王卫国,黄卫,阮慧文等.膜进样质谱技术及其应用[J].分析测试学报,2022,41(02):283-289.

WANG Wei-guo,HUANG Wei,RUAN Hui-wen,et al.Membrane Inlet Mass Spectrometry Techniques and Their Applications[J].Journal of Instrumental Analysis,2022,41(02):283-289.
王卫国,黄卫,阮慧文等.膜进样质谱技术及其应用[J].分析测试学报,2022,41(02):283-289. DOI： 10.19969/j.fxcsxb.21050702.

WANG Wei-guo,HUANG Wei,RUAN Hui-wen,et al.Membrane Inlet Mass Spectrometry Techniques and Their Applications[J].Journal of Instrumental Analysis,2022,41(02):283-289. DOI： 10.19969/j.fxcsxb.21050702.

摘要

膜进样质谱（MIMS）具有简单、快速和高灵敏等优点，在现场检测中的应用日益广泛。该技术利用半透膜将目标化合物从复杂的气相、液相体系中选择性分离后进入质谱进行分析检测。由于其可在不经色谱分离和样品前处理条件下实现复杂实际样品的分析，特别适合于现场应用。该文综述了膜进样质谱的原理和主要组成，重点论述了膜进样－单光子软电离质谱方面的技术进展以及膜进样质谱在环境、生态学、生命科学、生物等领域的应用进展。最后，对膜进样质谱今后的发展趋势进行了总结和展望。

Abstract

Membrane inlet mass spectrometry（MIMS） utilizes a semi-permeable membrane to selectively transfer the target molecules in gas，liquid or solid mixtures into a mass spectrometer，yielding on line monitoring volatile organic compounds. It has been widely used for the continuous monitoring on line without chromatographic separation and sample pretreatment，where the inferences from the bulk of the sample matrix could be avoided．In this review，the principle and structure of MIMS instrument were introduced，including the membrane materials，ionization sources，the mass spectrometers and also interface configurations．The progresses of MIMS instruments in the laboratory were presented，especially on the combination of membrane with the single photon ionization time of flight mass spectrometry．A new membrane inlet with buffer cell for time of flight mass spectrometry was developed to increase the limit of detection．Then，the combination of helical hollow fiber membrane inlet with time of flight mass spectrometry and ion mobility spectrometry was introduced for detection trace volatile organic compounds in air and water．Moreover，the in-source stretched hollow fiber membrane inlet and in-source helical hollow fiber membrane interface were also developed for higher limit of detection and faster responding time．Recently，MIMS has been widely used in a lot of field including environmental pollutions monitoring，also the field of ecology，life sciences，microbial metabolism．In the field of environment，some methods based on MIMS were developed to measure the chlorinated and brominated-amines，aromatic pollutants in drinking water．MIMS also was used for direct analysis of the naphthenic acids in constructed wetland samples and polyaromatic hydrocarbons in soil and aqueous samples．In the field of ecology，MIMS was used to investigate the abundance and concentration of aqueous nitrate，nitrite and ammonium．It also used to measure the denitrification，anammox，DNRA rates，and net N,2, flux in paddy soil．In the field of life sciences，membrane inlet ion mobility spectrometry was used for on-line measurement of trace propofol in exhaled air．MIMS was used to detect the representative bacteric metabolites and classify four kinds of bacteria．In the field of microbial metabolism，MIMS was used for quantitative understanding of inorganic carbon uptake flux and carbon concentrating mechanisms in metabolically engineered cyanobacteria．MIMS was also used to study the CO,2, and HCO, $3 -$ ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=37279933&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=37279928&type=,1.18533325,4.31799984, permeabilities of isolated chloroplasts and the conversion of nitric oxide into nitrous oxide by algal photosynthesis．The new applications of membrane inlet mass spectrometry in recent years were presented，and the potential trends in future were also looked forward to，namely，1） to develop the quantitative method based on MIMS；2） to improve the sensitivity and portability of MIMS for field applications；3） to extend the new application field such as the monitoring the volatile organic compounds in marine environment with MIMS．

关键词

膜进样质谱电离源应用

Keywords

membrane inletmass spectrometryionization sourceapplication

references

Adrien B，Yonghua L B，Gilles P．Plant Physiol.，2020，183：451－454.

Krogh E T，Gill C G．J. Mass Spectrom.，2014，49：1205－1213.

Li B Q，Li C P，Zhang Z Y，Kong J L，Zhang L．J. Chin. Mass Spectrom. Soc. （李宝强，李翠萍，张众垚，孔景临，张琳．质谱学报），2018，39（6）：715－721.

Long X W，Zhao J P，Song C L，Sun X T，Wang W J，Yan F X，Ling D P，Chen N．Ship Sci. Technol. 龙希伟，赵加鹏，宋春丽，孙喜堂，王文锦，严奉轩，凌大鹏，陈宁．舰船科学技术），2017，39（8）：100－103.

Tan G B，Gao W，Hong Y，Huang Z X，Li M，Dong J G，Cheng P，Fu Z，Zhou Z．Mod. Sci. Instrum. 谭国斌，高伟，洪义，黄正旭，李梅，董俊国，程平，傅忠，周振．现代科学仪器），2011，5（3）：59－62.

Ketola R A，Kotiaho T，Cisper M E，Allen T M．J. Mass Spectrom.，2002，37：457－476.

Davey N G，Krogh E T，Gill C．Trends Anal. Chem.，2011，30：1477－1485.

Bell R J，Short R，Van Amerom F H W，Byrne R H．Environ. Sci. Technol.，2007，41：8123－8128.

Zhang L，Li C P，Cao B Q，Shao C Y，Ding X Q．Anal. Instrum. （张琳，李翠萍，曹丙庆，邵晟宇，丁学全．分析仪器），2010，4：1－6.

Hou K Y，Wang J D，Li H Y．Rapid Commun. Mass Spectrom.，2007，21：3554－3560.

Liu W，Qi Y C，Jiang J C，Li J X，Zhou L J，Hua L，Hou K Y，Li H Y．J. Chin. Mass Spectrom. Soc. 刘巍，齐雅晨，蒋吉春，李金旭，周丽娟，花磊，侯可勇，李海洋．质谱学报），2018，39（2）：141－148.

Liang X X，Chen C，Wang W G，Li H Y．Chin. J. Chromatogr. （梁茜茜，陈创，王卫国，李海洋．色谱），2014，32（8）：837－842.

Du Y Z，Zhang W，Whitten W，Li H Y，Watson D B，Xu J．Anal. Chem.，2010，82：4089－4096.

Hou K Y，Li F L，Chen W D，Chen P，Xie Y Y，Zhao W D，Lei H，Pei K M，Li H Y．Analyst，2013，138（17）：5826－5831.

Li F L，Hou K Y，Chen W D，Chen P，Zhao W D，Cui H P，Hua L，Xie Y Y，Pei K M，Li H Y．Chin. J. Anal. Chem.

李芳龙，侯可勇，陈文东，陈平，赵无垛，崔华鹏，花磊，谢园圆，裴克梅，李海洋．分析化学），2013，41（1）：42－48.

Wu C X，Liu W，Jiang J C，Wang Y，Hou K Y，Li H Y．Talanta，2019，192：46－51.

Hu W，Lauritsen F R，Allard S．Sci. Total Environ.，2021，751：142303.

Duncan K D，Richards L C，Monaghan J，Simair M C，Ajaero C，Peru K M，Friesen V，McMartin D W，Headley J V，Gill C G，Krogh E T．Sci. Total Environ.，2020，716：137063.

Vandergrift G W，Monaghan J，Krogh E T，Gill C G．Anal. Chem.，2019，91：1587－1594.

Vandergrift G W，Krogh E T，Gill C G．Anal. Chem.，2020，92：15480－15488.

Gehm C，Streibel T，Ehlert S，Schulz－Bull D，Zimmerman R．Rapid Commun. Mass Spectrom.，2021，35：e8863.

Duncan K D，Beach D G，Wright E J，Barsby T，Gill C G，Krogh E T．Anal. Methods，2018，10：3310.

Eschenbach W，Lewicka－Szczebak D，Stange C F，Dyckmans J，Well R．Anal. Chem.，2017，89（11）：6076－6081.

Eschenbach W，Well R，Dyckmans J．Anal. Chem.，2018，90（19）：11216－11218.

Li J F，Chai Y C，Chen S T，Shan J，Yan X Y．J. Agro－Environ. Sci. （李进芳，柴延超，陈顺涛，单军，颜晓元．农业环境科学学报），2019，38（7）：1541－1549.

Zheng W J，Han Y，Qin C，Zhang G L．Mar. Environ. Sci. （郑文静，韩玉，秦川，张桂玲．海洋环境科学），2016，35（4）：611－617.

Xie C J，Song G D，Liu S M，Tang J Y，Zhang G L．Acta Oceanol. Sin. （谢成军，宋国栋，刘素美，唐继尧，张桂玲．海洋学报），2020，42（2）：22－29.

Gerber D，Vasireddy R，Varadarajan B，Hartwich V，Schär M Y，Eberlel B，Vogt A．J. Clin. Monit. Comput.，2019，33：1033－1041.

Borden S A，Damer H N，Krogh E T，Gill C G．Anal. Bioanal. Chem.，2019，411：291－303.

Zhou Q H，Li E Y，Wang X，Gong Y L，Hua L，Wang W G，Qu T S，Li J H，Liu Y P，Wang C S，Li H Y．Anal. Methods，2014，6：698－703.

Zhou Q H，Wang W G，Cang H W，Du Y Z，Han F L，Chen C，Cheng S S，Li J H，Li H Y．Talanta，2012，98：241－246.

Wang J，Huang L J，Xu Z J，Liu Y，Xu J J，Chen H Y．Chin. J. Anal. Chem. （王姜，黄丽娟，徐贞俊，刘昱，徐静娟，陈洪渊．分析化学），2020，48（10）：1315－1324.

Douchi D，Liang F Y，Cano M，Xiong W，Wang B，Maness P C，Lindblad P，Yu J P．Frontiers in Microbiol.，2019，10：1356.

Tolleter D，Chochois V，Poiré R，Price G D，Badger M R．J. Exp. Bot.，2017，68：3915－3924.

Burlacot A，Richaud P，Gosset A，Li－Beisson Y，Peltier G．Proc. Natl. Acad. Sci. USA，2020，117：2704－2709.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Development and Application of Online Monitoring System for Odor Pollutants

Research Progress on Gut Microbiota Incubation Technique and Application in the Analysis of Traditional Chinese Medicine

Application of Aptamer Biosensor in Detection of Aflatoxin B1

Research and Application of Carbon Fiber Ionization Mass Spectrometry

Related Author

No data

Related Institution

China Tobacco Zhejiang Industrial Co. Ltd.

Hangzhou PuYu Technology Development Co. Ltd.

China Tobacco Zhejiang Industrial

Modern Research Center for Traditional Chinese Medicine，Shanxi University

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education，College of Chemistry and Chemical Engineering，Shanxi University

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰