Zr-based Metal-Organic Frameworks Selectively Targeted the Active Components of Alkaloids in Fishing Coptis <italic style="font-style: italic">chinensis</italic> Franch

SI Tian-tian; ZHAO Wei; WANG Hui; ZHANG Hong-yu; LIU Xiao-ye; RONG Rong; FENG Juan-juan

doi:10.12452/j.fxcsxb.240930425

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Zr-based Metal-Organic Frameworks Selectively Targeted the Active Components of Alkaloids in Fishing Coptis chinensis Franch

Scientific Papers | 更新时间：2025-01-03

- Zr-based Metal-Organic Frameworks Selectively Targeted the Active Components of Alkaloids in Fishing Coptis chinensis Franch
- Journal of Instrumental Analysis Vol. 44, Issue 1, Pages: 188-194(2025)
- 作者机构：
  
  1.山东中医药大学药学院，山东济南 250355
  2.济南大学化学化工学院，山东济南 250022
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.240930425
  CLC： O657.7;R284.2
- Published：15 January 2025，
  
  Received：30 September 2024，
  
  Revised：14 November 2024，
- 稿件说明：
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司甜甜,赵薇,王慧,张红玉,刘小烨,容蓉,冯娟娟.锆基金属有机框架捕获黄连中的生物碱类药物活性成分[J].分析测试学报,2025,44(01):188-194.

SI Tian-tian,ZHAO Wei,WANG Hui,ZHANG Hong-yu,LIU Xiao-ye,RONG Rong,FENG Juan-juan.Zr-based Metal-Organic Frameworks Selectively Targeted the Active Components of Alkaloids in Fishing Coptis chinensis Franch[J].Journal of Instrumental Analysis,2025,44(01):188-194.
司甜甜,赵薇,王慧,张红玉,刘小烨,容蓉,冯娟娟.锆基金属有机框架捕获黄连中的生物碱类药物活性成分[J].分析测试学报,2025,44(01):188-194. DOI： 10.12452/j.fxcsxb.240930425.

SI Tian-tian,ZHAO Wei,WANG Hui,ZHANG Hong-yu,LIU Xiao-ye,RONG Rong,FENG Juan-juan.Zr-based Metal-Organic Frameworks Selectively Targeted the Active Components of Alkaloids in Fishing Coptis chinensis Franch[J].Journal of Instrumental Analysis,2025,44(01):188-194. DOI： 10.12452/j.fxcsxb.240930425.

摘要

采用溶剂热法制备了锆基MOF-808，利用其结构优势实现了中药黄连中生物碱类药物活性成分的富集与捕获，并结合其结构特点探讨了其协同低共熔溶剂捕获生物碱类活性成分过程中的相互作用。通过优化孵育捕获等条件，对黄连粗提液中药根碱的回收率达到85.78%，结合高效液相色谱技术建立了检测黄连粗提液中5种生物碱类活性成分的方法。方法的线性范围为0.1~300 µg·L

-1

，检出限为0.02~0.05 µg·L

-1

，相对标准偏差为0.40%~4.7%，加标回收率达到69.7%~128%。该研究实现了中药黄连中生物碱类活性成分的高效、快速富集与捕获，为MOFs材料在选择性捕获与富集中药有效成分等领域的研究提供了新思路。

Abstract

Metal-organic frameworks（MOFs），owing to their readily modifiable structural features and distinctive molecular sieve effects，enable efficient enrichment of target compounds，thereby exhibiting vast potential applications in fields such as environmental science，food safety and medicinal health. In this study，MOF-808 was as carriers to achieve enrichment and extraction of alkaloid bioactive components from Coptis

chinensis

（Huanglian）. Furthermore，we delved into the synergistic interactions during the extraction process of these alkaloids using MOFs in conjunction with low-co-solvent systems，based on their structural characteristics. By optimizing conditions such as incubation and extraction procedures，it achieved a remarkable recovery of 85.78% for jatrorrhizine from crude extracts of Huanglian. In addition，it boasted a wide linear range spanning from 0.1 to 300 µg·L

-1

，with ultra-low detection limits ranging from 0.02-0.05 µg·L

-1

and relative standard deviations maintained within 0.40%-4.7%. Additionally，for jatrorrhizine，epiberberine，coptisine，palmatine and berberine in the Huanglian crude extract matrix，the spiked recoveries reached an impressive range of 69.7% to 128%. This approach efficiently and rapidly enriches and extracts alkaloid bioactive components from the Huanglian，thereby offering a novel perspective for the research on the selective extraction and enrichment of active ingredients in traditional Chinese medicines using MOFs materials.

关键词

金属有机框架选择性富集色谱分离生物碱活性成分黄连

Keywords

metal-organic frameworkselective enrichmentchromatographic separationactive ingredients of alkaloidsCoptis chinensis

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Zr-based Metal-Organic Frameworks Selectively Targeted the Active Components of Alkaloids in Fishing Coptis chinensis Franch

DOI：10.12452/j.fxcsxb.240930425

摘要

Abstract

关键词

Keywords

references