As fundamental materials of advanced materials and chemical metrological traceability，high purity metals play an important role. The impurity and purity values are important indicators of them. The total purity analysis，means deducting all elemental impurities including non-metals and gas elements，has become an authoritative method for determining the purity of high purity metals. With high purity gold certified reference material（GBW02793） as an example，this paper described in detail the research points of various methods in total purity analysis，including glow discharge mass spectrometry，high resolution inductively coupled plasma mass spectrometry，combustion infrared absorption and inert gas fusion infrared absorption methods. A systematic correction has been made to the relative sensitivity factor，which is an important factor causing measurement bias in glow discharge mass spectrometry method，reducing the measurement uncertainty from 200% to 30%. High mass fraction of metallic elemental impurities Na，Fe and Cu were measured by using glow discharge mass spectrometry and high resolution inductively coupled plasma mass spectrometry. Both results were agreed with each other. Trace gas elements H，C，N，and S were detected by combustion infrared absorption method and inert gas fusion infrared absorption method. And all of them were lower than the limits of quantitative，which were 0.35 mg/kg，0.51 mg/kg，0.45 mg/kg，and 0.85 mg/kg，respectively. Trace oxygen was measured by using inert gas fusion infrared absorption method and secondary ion mass spectrometry. Two measurement results were close. A reasonable evaluation was conducted on the mass fractions of inert gas elements and radioactive elements，and the uncertainty of gold purity was evaluated. Finally，the determination method of total purity of high purity gold was established. The mass fraction of gold in high purity gold certified reference material was 99.999 5% and the extended uncertainty was 0.000 2%.