Determination of Emerging Contaminants of <italic style="font-style: italic">p</italic>-Phenylenediamine Quinones in Human Urine Samples by UPLC-HRMS

ZHANG Jing; CAO Guo-dong; WANG Wei; QIAO Han; DAI Qing-yuan; CAI Zong-wei

doi:10.12452/j.fxcsxb.24052991

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Determination of Emerging Contaminants of p-Phenylenediamine Quinones in Human Urine Samples by UPLC-HRMS

Scientific Papers | 更新时间：2024-08-08

- Determination of Emerging Contaminants of p-Phenylenediamine Quinones in Human Urine Samples by UPLC-HRMS
- Journal of Instrumental Analysis Vol. 43, Issue 8, Pages: 1197-1203(2024)
- 作者机构：
  
  香港浸会大学化学系，环境与生物分析国家重点实验室，香港 999077
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.24052991
  CLC： O657.63;X132
- Published：15 August 2024，
  
  Received：29 May 2024，
  
  Revised：27 June 2024，
- 稿件说明：
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张婧,曹国栋,王威,乔涵,戴情园,蔡宗苇.超高效液相色谱-串联高分辨质谱法检测人体尿液中的对苯二胺-醌类新污染物[J].分析测试学报,2024,43(08):1197-1203.

ZHANG Jing,CAO Guo-dong,WANG Wei,QIAO Han,DAI Qing-yuan,CAI Zong-wei.Determination of Emerging Contaminants of p-Phenylenediamine Quinones in Human Urine Samples by UPLC-HRMS[J].Journal of Instrumental Analysis,2024,43(08):1197-1203.
张婧,曹国栋,王威,乔涵,戴情园,蔡宗苇.超高效液相色谱-串联高分辨质谱法检测人体尿液中的对苯二胺-醌类新污染物[J].分析测试学报,2024,43(08):1197-1203. DOI： 10.12452/j.fxcsxb.24052991.

ZHANG Jing,CAO Guo-dong,WANG Wei,QIAO Han,DAI Qing-yuan,CAI Zong-wei.Determination of Emerging Contaminants of p-Phenylenediamine Quinones in Human Urine Samples by UPLC-HRMS[J].Journal of Instrumental Analysis,2024,43(08):1197-1203. DOI： 10.12452/j.fxcsxb.24052991.

摘要

该文建立了一种基于液液萃取的超高效液相色谱-串联高分辨质谱测定人体尿液中5种新污染物对苯二胺-醌（PPD-Qs）的方法。优化确定了样品前处理条件及色谱、质谱仪器参数，并采用氘代N-（1，3-二甲基丁基）-N

-苯基-对苯二胺醌（6PPD-Q-D

）作为内标进行定量分析。结果表明，该方法在0.01~50 ng/mL范围内线性关系良好，相关系数大于0.999，方法检出限低至2.4~7.5 pg/mL。尿液中5种PPD-Qs的基质效应为81.3%~110%；3种不同浓度水平加标样本的平均回收率为80.5%~114%，日内及日间相对标准偏差（RSD）均不大于11%。将该方法应用于人群队列尿液中5种PPD-Qs的检测，5种PPD-Qs的平均质量浓度为0.04~1.06 ng/mL。该方法操作简单、灵敏度高、重复性好，适用于人体尿液中新污染物PPD-Qs的检测。

Abstract

A liquid-liquid extraction based ultra-high performance liquid chromatography-high resolution mass spectrometry（UPLC-HRMS） method was developed for the determination of 5 emerging contaminants of

-phenylenediamine quinones（PPD-Qs） in human urine. The process of sample pretreatment and parameters of both chromatography and mass spectrometry were optimized in detail. Using 6PPD-Q-D

as an internal standard，the method established in this study had a good linear relationship in the range of 0.01-50 ng/mL，whereas the linear correlation coefficients were greater than 0.999，and the detection limits of the method（LODs） were as low as 2.4-7.5 pg/mL. The matrix effects of the

five PPD-Qs in urine samples were detected at 81.3%-110%. The average recoveries were 80.5%-114%，and intra-day and inter-day relative standard deviations（RSDs） were less than 11%. The method was applied to the determination of 5 PPD-Qs in human urine samples，and the mean concentrations of 5 PPD-Qs ranged from 0.04 ng/mL to 1.06 ng/mL. The method in our study has the advantages of simple operation，high sensitivity，and good repeatability，which is suitable for the determination of PPD-Qs in human urine.

关键词

对苯二胺类抗氧化剂对苯二胺-醌新污染物超高效液相色谱-串联高分辨质谱尿液

Keywords

p-phenylenediamine（PPDs） antioxidantsp-phenylenediamine quinones（PPD-Qs）emerging contaminantsUPLC-HRMSurine

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Determination of Emerging Contaminants of p-Phenylenediamine Quinones in Human Urine Samples by UPLC-HRMS

DOI：10.12452/j.fxcsxb.24052991

摘要

Abstract

关键词

Keywords

references