Electrochemical Aptasensor Based on Bimetallic Composites for Detection of Sulfadimethoxine

YAN Bin; WU Yi-jie; LIAO Xing-xing; BAI Li-juan

doi:10.12452/j.fxcsxb.24011901

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Electrochemical Aptasensor Based on Bimetallic Composites for Detection of Sulfadimethoxine

Scientific Papers | 更新时间：2024-08-16

- Electrochemical Aptasensor Based on Bimetallic Composites for Detection of Sulfadimethoxine
- Journal of Instrumental Analysis Vol. 43, Issue 5, Pages: 755-762(2024)
- 作者机构：
  
  1.重庆市第八中学校，重庆 400030
  2.重庆医科大学药学院，重庆 400016
- 作者简介：
- 基金信息：
- DOI：10.12452/j.fxcsxb.24011901
  CLC： 0657.1;TB741
- Published：15 May 2024，
  
  Received：19 January 2024，
  
  Revised：28 March 2024，
- 稿件说明：
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鄢斌,吴依洁,廖星星,白丽娟.基于双金属材料的电化学适体传感器用于磺胺二甲氧嘧啶检测[J].分析测试学报,2024,43(05):755-762.

YAN Bin,WU Yi-jie,LIAO Xing-xing,BAI Li-juan.Electrochemical Aptasensor Based on Bimetallic Composites for Detection of Sulfadimethoxine[J].Journal of Instrumental Analysis,2024,43(05):755-762.
鄢斌,吴依洁,廖星星,白丽娟.基于双金属材料的电化学适体传感器用于磺胺二甲氧嘧啶检测[J].分析测试学报,2024,43(05):755-762. DOI： 10.12452/j.fxcsxb.24011901.

YAN Bin,WU Yi-jie,LIAO Xing-xing,BAI Li-juan.Electrochemical Aptasensor Based on Bimetallic Composites for Detection of Sulfadimethoxine[J].Journal of Instrumental Analysis,2024,43(05):755-762. DOI： 10.12452/j.fxcsxb.24011901.

摘要

开发能够精准检测磺胺二甲氧嘧啶（SDM）的方法在食品安全领域至关重要。该研究利用具有优异电化学活性的镍锌双金属微花（Ni-Zn MFs）作为生物传感平台，同时，引入金锰纳米粒子（AuMn NPs）修饰的还原氧化石墨烯（rGO）作为电信号抑制单元（AuMn/rGO，AMG）。在此基础上，设计了一种用于测定SDM的高灵敏生物传感器。当目标物SDM存在时，能与SDM的结合适配体（Apt）标记的AMG（AMG-Apt）特异性结合，将电信号抑制单元带离电极表面，放大氧化还原探针［Fe（CN）

］

3-/4-

的电化学信号变化。提出的用于检测SDM的适配体传感器在1 pg/mL~100 ng/mL范围内表现出良好的线性关系，检出限（LOD）低至0.26 pg/mL。此外，该生物传感器在牛奶样品中也表现出令人满意的结果，有望在食品安全分析中应用。

Abstract

The development of detection techniques for the accurate determination of sulfadimethoxine（SDM） is crucial in food safety. In this study，nickel-zinc bimetallic microflowers（Ni-Zn MFs） with excellent electrochemical activity were utilized as an electrochemical sensing platform，while reduced graphene oxide（rGO） modified with Aurum-Manganese nanoparticles（AuMn NPs） was introduced as an electrical signal hindering molecule（AuMn/rGO，AMG）. On this basis，a highly sensitive biosensor for the determination of SDM was developed. When SDM is present，it can specifically bind to the binding Aptamer（Apt）-labeled AMG（AMG-Apt），which carries the electrical signal hindering molecules away from the electrode surface and amplifies the electrochemical signal of the redox probe ［Fe（CN）

］

3-/4-

. The proposed aptasensor for the detection of SDM showed good linearity in the range of 1 pg/mL-100 ng/mL with a low limit of detection（LOD） of 0.26 pg/mL. Notably，this biosensor also showed satisfactory results in milk samples，which is expected to be ap

plied in food safety analysis.

关键词

电化学检测双金属适配体传感器磺胺二甲氧嘧啶（SDM）

Keywords

electrochemical detectionbimetalsaptasensorsulfadimethoxine（SDM）

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