Trimethylolpropane，tetrahydrofurfuryl alcohol and 1，6-hexanediol are the raw materials or additives used in the production of laminated films and pouches for food packaging．These three substances may remain in products and migrate into food，thus affecting human health．Specific migration limits（SML） for the above three substances are clearly stipulated in the relevant standards of China．Therefore，it is extremely necessary to establish a targeted detection method for the migration of the above three alcohols in laminated films and pouches for food packaging．A liquid chromatography－tandem mass spectrometry（LC－MS/MS） was established for the simultaneous determination of trimethylolpropane，tetrahydrofurfuryl alcohol and 1，6-hexanediol in laminated films and pouches for food packaging in this paper. Laminated films and pouches were treated with different simulants according to related regulations and standards. After soaking in food simulants， the simulated samples were pretreated with appropriate manners．Water-based，acid-based and part of alcohol-based（ethanol contents are equal to or less than 10% by volume） simulated samples were directly filtered．Other alcohol-based（ethanol contents are more than 10% by volume） simulated samples were adjusted to their original volume with water after removing most of alcohol by nitrogen blowing．The olive oil simulated sample was detected after extraction with 10% methanol solution．The separation was performed on an C,18, column by gradient elution with formic acid（0.01%） and acetonitrile as mobile phases．The detection was performed with electrospray ion source in positive ion（ESI,+,） under multi reaction monitoring（MRM） mode．Meanwhile，external standard method was used for quantitative determination．Results indicated that this method exhibited perfect linear relationships for the 3 alcohols，with their correlation coefficients（,r,） more than 0.999．The recoveries at three spiked levels ranged from 88.9% to 116%，with relative standard deviations（RSD） of 0.70%－5.0%．The limits of detection（LODs，,S,/,N ,≥ 3） and limits of quantitation（LOQs，,S,/,N ,≥ 10） for trimethylolpropane in olive oil were 20 µg/kg and 40 µg/kg，respectively，and the LODs and LOQs for both tetrahydrofurfuryl alcohol and 1，6-hexanediol in olive oil were 4 µg/kg and 10 µg/kg，respectively．Meanwhile，the LODs and LOQs for the 3 alcohols in other food simulants were 4 µg/L and 10 µg/L，respectively．The method is simple，reliable，sensitive and stable．The food simulants included in the method basically covered the types specified in the regulations and standards．The LODs and LOQs of the method were lower than the specific migration limits（SML） specified in the regulations and standards．The method could meet the needs for migration determination of 3 alcohols in laminated films and pouches for food packaging.