A method of ultra high performance liquid chromatography（UPLC） was developed for the quantitative determination of 10 active components in Yinlai decoction,which was subsequently used for the quality evaluation of Yinlai decoction.The chromatographic separation was performed on a Waters ACQUITY UPLC HSS T3 column（2.1 mm×100 mm,1.8 μm） by gradient elution with 0.1% formic acid water and 0.1% formic acid acetonitrile as mobile phases.The detection wavelength was firstly set at 320 nm for neochlorogenic acid,chlorogenic acid,cryptochlorogenic acid,sinapine thiocyanate,forsythoside I in the first 10 min,then switched to 350 nm for forsythoside A,quercitrin from 10 to 16 min,and finally switched to 320 nm for baicalin,oroxylin A-7-O-β-D-glucuronide,wogonoside from 16 to 30 min.Results showed that the method completed the baseline separation for 10 active components in Yinlai decoction within 30 min.There were good linear relationships for 10 components in the certain concentration ranges with their correlation coefficients（r） not less than 0.999 2.The limits of detection and limits of quantitation were in the ranges of 0.018 8-0.075 0 μg·mL-1 and 0.062 5-0.250 μg·mL-1,respectively.The content range for 10 components ranged from 0.204 to 38.129 mg·g-1,in which baicalin was the highest,while quercitrin was the lowest.The method was used in the detection of three batches of sample,and it was found that the contents of the measured components were stable and consistent.The established analytical indexes are relatively comprehensive,reasonable and feasible,and could be used for better characterization and evaluation of the quality of Yinlai decoction.