Lipidomics is a new branch of science relying on analytical techniques,which is used to fully characterize the lipid molecules related closely to gene regulation,protein expression and lipid metabolism.With the further development of mass spectrometry and its coupled technologies,lipidomics has been gradually becoming rapid,automated and high throughput.However,data processing in large scale lipidomics analysis is still highly challenging.Chemometrics is mainly used in the baseline correction and background deduction,chromatographic peak identification,isotope distribution resolving,etc.Therefore,automated data processing strategies based on chemometrics have attracted attentions from many researchers.In this paper,the chemometric methods applied in lipidomics data processing in recent years are briefly reviewed,and the future development tendency of automated data processing in lipidomics are also prospected.