Sulfonamides(SAs) residues are closely related to food safety level.Development of rapid,efficient and highly selective pretreatment methods is the key point for determination of SAs owing to the presence of complicated matrices.Solid phase extraction(SPE),featuring with low solvent consumption,environmental friendliness,high selectivity,high sensitivity,timesaving,low cost and compatibility with different detection methods,has been widely applied in the sample pretreatment for SAs.In this review,advances of SPE application in the analysis of SAs are summarized,mainly including pipette tip SPE,magnetic SPE,molecularly imprinted SPE,in tube SPE and other SPE.