kind of novel fluorescence carbon quantum dots(CDs) were fabricated by microwave heating method using L aspartic acid and urea as the precursors.The obtained CDs exhibited good spherical shapes with an average size about 5 nm.In addition,the CDs were characterized by Fourier transform infared spectroscopy,X-ray photoelectron spectroscopy,ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy.The CDs showed high fluorescence stability,good particle dispersion,excellent water solubility and remarkable selectivity toward isorhamnetin(ISOR).Under the optimized conditions,there was a good relationship between fluorescence quenched degree(IF0/IF) of the CDs and concentration of ISOR in the range of 0.22-180 nmol/L with a limit of detection(LOD) of 1.32 nmol/L.The CDs were successfully applied in the detection of ISOR in ginkgo biloba tablets with recoveries of 90.8%-107%.Results showed that the as synthesized CDs could be used in ISOR detection with rapidness,efficiency and sensitivity.