An analytical method was established for the determination of 88 pesticide residues in Pericarpium citri reticulatae by improved QuEChERS pretreatment combined with gas chromatography tandem mass spectrometry(GC-MS/MS) in dynamic multi reaction monitoring mode.Screening and optimizing of sample extraction methods,acetonitrile as extraction solvent,then added with 40 g anhydrous magnesium sulfate and 1.0 g anhydrous sodium acetate,followed by ceramic proton extraction,200 mg PSA,100 mg C18 and 30 mg GCB purification,and finally corrected by matrix matching external standard method.Influences of matrix effect on the quantification accuracy for target compounds in Pericarpium citri reticulatae were significantly weakened.The calibration curves for 88 pesticides exhibited good linearity in a certain concentration range,with their correlation coefficients(r2) not less than 0.996 3.The limits of detection(S/N=3) and the limits of quantification(S/N=10) were 0.001 0-0.050 0 mg/kg and 0.002-0.100 0 mg/kg,respectively.Moreover,the average recoveries at low,medium and high spiked levels ranged from 60.1% to 118% with the relative standard deviations(RSDs,n=6) ranged from 0.30% to 13%.The method was fast,efficient,sensitive and reliable,and was suitable for the rapid screening and routine detection of pesticide residues in Pericarpium citri reticulatae.