Design and development of fast,reliable,cheap and high throughput DNA sequencing could be the most revolutionary significance for preventing early disease and understanding the mechanisms of related diseases.Due to its distinctive structures and properties,the new nanomaterials graphene is playing an important role in many areas such as chemistry and bioscience.In this review,we describe the research states of DNA sequencing and the advantages of the application of graphene nanomaterials.The different current signals generated by DNA chains through graphenenanopore,graphenenanogap and graphene nanoribbon to identify base sequences are discussed in detail.The effect of interaction between DNA chains and graphene on DNA sequencing isfurther discussed,and the future research of DNA sequencing is also prospected.It provides referencesof working principle,theoretical research and detection methods of DNA sequencing based on graphene nanomaterials.