A solid phase micro extraction(SPME)/gas chromatography-mass spectrometry(GC-MS) was established for the detection of volatile compounds in edible bird's nest(EBN) derived from Indonesia.The samples were extracted by SPME and identified by GC-MS.Effects of type of SPME column,extraction time,extraction temperature and desorbing time on extraction efficiencies for volatile compounds in EBN were investigated.Results indicated that 82 kinds of alcohols,hydrocarbons,aldehydes,esters,ethers,and etc.in EBN were detected with a 65 μm polydimethylsiloxane/divinylbenzene(PDMS/DVB) fused silica fiber at 60 ℃ for extraction time of 60 min and desorbing time of 2 min.With the characteristics of easy operation,rapidness,high repeatability and high sensitivity,the method is suitable for determination of the volatile compounds in EBN.