A two-dimensional gas chromatography-time of flight mass spectrometry(GC×GC-TOF MS) was developed for the determination of 50 substances of very high concern(SVHCs) in plastic,including 24 polycyclic aromatic hydrocarbons,17 phthalates,3 alkyl phenols,4 benzotriazole ultraviolet stabilizers,karanal and triphosphate(2-chloroethyl) ester.Samples were shattered and extracted with methanol by ultrasonic extraction.The qualitative analyses were performed by TOF MS.The quantitative analyses were performed by external standard method.Results showed that there were good linear relationships for 50 analytes in the concentration range of 0.05-15 mg/L with their correlation coefficients(r2) not less than 0.990 4.The limits of detection(LODs) and limits of quantitation(LOQs) were in the ranges of 0.04-5.96 mg/kg and 0.05-13.39 mg/kg,respectively.The recoveries at low,medium and high spiked levels ranged from 80.0% to 121% with relative standard deviations(RSDs,n=6) of 1.1%-13%.Phthalates and Polycyclic aromatic hydrocarbons were detected when this method was applied to the detection for real samples.This method could be used for the simultaneous screening and confirmation of 50 SVHCs in plastic with accuracy and efficiency.