A high performance liquid chromatography-tandem mass spectrometric(HPLC-MS/MS) method was developed for the simultaneous determination of ractopamine and clenbuterol in processed meats.A new cation exchange chromatographic column was utilized to separate target compounds and an improved pre-treatment method was uesed in this study.The eluent solution types and chromatographic parameters were optimized. The optimal conditions were as follows: using a flow rate of 0.4 mL?min-1，a injection volume of 10 μL and a column temperature of 40 ℃.The homogenized samples were extracted with 0.02 mol?L-1 ammonium acetate(pH 5.2)，hydrolyzed with 30 μL β-glucuronidase/arylsulfatase，centrifuged，and cleaned through solid phase extraction column. The calibration curves showed good linearities for two target compounds in the range of 0.1-100 μg?L-1.The limits of detection and quantitation of two target compounds were not more than 0.04 μg/kg and 0.15 μg/kg，respectively.The spiked recoveries for the processed meats ranged from 72% to 98% with RSDs less than 8.5%.This proposed method was simple and sensitive,and was suitable for the quantification of ractopamine and clenbuterol in processed meats.