As the third generation of genetic marker，the analysis of single nucleotide polymorphisms （SNPs） has a great significance for the pathogeny and early medical diagnosis of gene diseases，and has become a hotspot of analytical chemistry and life science research.In recent years，the electrochemical biosensors have been widely used in SNPs assay due to its advantages of high-sensitivity，simple-design，low-cost，easy miniaturization and automation.In this paper，the principle of SNPs typing，electrochemical biosensor technology and signal amplification methods for SNPs are introduced.Moreover，the current research progress on electrochemical detection for SNPs is summarized，and the future direction of SNPs electrochemical detection is discussed.