An inductively coupled plasma optical emission spectrometric （ICP-OES） method was developed for the determination of metallic impurities in pharmaceutical ingredients.The samples were directly dissolved with organic mixed solvent （DMSO∶H2O=4∶1）.The conditions of instrument were optimized，and the 14 metal elements listed in EMEA guidance could be rapidly analyzed by the method.The detection limits were less than 0.30 mg/kg，and the recoveries of the 14 metal elements ranged from 90% to 115%.The data was compared with those obtained from the different treatment methods.The results showed that the method,with the advantages of simplicity，easy operation and high accuracy，was suitable for the quick determination of multi-elements in large quantities of samples.