A micellar electrokinetic capillary chromatographic（MECC） method was established for the separation and determination of three active components，including caffeine，paracetamolum and aspirin，in Paracetamol Caffeine Aspirin Powder.The micellar phase of cholic acid combined with improver of organic base triethanolamine was optimized.The optimal electrophoretic conditions were as follows：buffer：40 mmol/L borate-60 mmol/L cholic acid-12.5% triethanolamine （pH 12.0），separated voltage：15 kV,detection wavelength：254 nm.Under the optimum conditions，the baseline separation of three components in Paracetamol Caffeine Aspirin Powder was achieved within 14 min.The linear calibration curves were in the ranges of 18.75-900.0 mg/L （r=0.999 9） for caffeine，2.60-62.50 mg/L （r=0.992 9） for paracetamolum and 79.17-3 800 mg/L （r=0.994 0） for aspirin.The relative standard deviations of three components were no more than 1.8% for migration time and 6.8% for peak height.The detection limits （S/N=3） were 4.6，0.17,38 mg/L，respectively.The spiked recoveries of three components in Paracetamol Caffeine Aspirin Powder were 100%，100% and 102%，respectively，which could meet the requirement for analyzing reality sample.The improved method is simple，reliable，sensitive and economical，and is suitable for the separation and determination of the multiple ingredients in Paracetamol Caffeine Aspirin Powder.