A rapid resolution liquid chromatography-tandem mass spectrometric(RRLC-MS/MS) method was firstly developed for the determination of Congo red in meat products.Homogenized samples were extracted with acetonitrile-n-hexane mixture(1∶1) and the acetonitrile extraction were transferred for immediate testing after centrifugated by 15 000 r/min for 10 min.The target compound was separated on an Agilent XDB C18 column with acetonitrile-10 mmol/L ammonium formate as mobile phase by gradient elution,and determined by tandem mass spectrometry with multiple reaction monitoring(MRM) mode under negative electrospray ionization mode.The two precursor-product ion pairs,m/z 325.0/416.0 and m/z 651.0/152.0,were used as the quantizative and qualificative ions,respectively.The external standard method was used for quantitative analysis.The results showed a good linearity in range of 0.1-10 mg/L with correlation coefficients higher than 0.999.The average recoveries of three spiked levels including high,medium and low concentrations were between 91% and 102%,with relative standard deviations(RSDs) of 1.2%-4.0%.The limits of detection(LODs) and limits of quantitation(LOQs) were 0.07 mg/kg and 0.18 mg/kg,respectively.The proposed method was accurate and high efficient,and could meet the requirements for the rapid detection of Congo red in meat products.