A comprehensive analytical method for the determination of bisphenol A,octylphenol and nonylphenol in skin care cosmetics was developed using ultra performance liquid chromatography with tandem mass spectrometry（UPLC-MS/MS）.The homogenized sample was extracted with methylene chloride.Sample concentration and purification were performed on an OASIS NH2 solid phase extraction cartridge.The separation of 4 compounds was carried out on a Waters UPLC BEH C18 column by gradient elution with methanol-0.5% NH3?H2O as mobile phase.The analytes were detected under multiple reaction monitoring（MRM） with electrospry ionization in negative ion mode（ESI-）,identified with retention time and ion ratio,and quantified by the external standard method.Under the optimal conditions，the separation of analytes was performed within 5 min.The calibration curves for four compounds were linear in the range of 0.5-50.0 μg/L with correlation coefficients more than 0.999.The quantitation limits were 0.5 μg/kg．The mean recoveries for four compounds in skin water and skin cream samples at three spiked concentration levels of 0.5，1.0，10.0 μg/kg were in the range of 80%-96% with RSDs（n=6） less than 15%．This method is accurate,simple and rapid,and is suitable for the inspection of bisphenol A,octylphenol and nonylphenol in skin care cosmetics.