A comprehensive analytical method based on liquid chromatography-tandem mass spectrometry was developed for the determination of α,β,γ-hexabromocyclododecane in polymer food contact materials.The samples were ultrasonically extracted with acetone as extraction solvent.The extract was cleaned up with ENVI-Carb Ⅱ/PSA solid phase extraction cartridge.The separation of the analyte was performed on a Waters XBridge C18 (150 mm×2.1 mm,3.5 μm) column using methanol-acetonitrile-water(41∶41∶18) as mobile phase by isobaric elution.The qualitative and quantitative analysis of the analyte were carried out under the multiple reaction monitoring(MRM) mode.The limits of quantitation(LOQs) for α,β,γ-hexabromocyclododecane were all 40 μg/kg.The mean recoveries at three spiked levels of 40.0-160.0 μg/kg were in the range of 86%-91%,with relative standard deviations(RSDs) of 1.9%-4.7%.The method was accurate,rapid and sensitive and was applicable to the inspection of hexabromocyclododecane in food contact materials.