Based on the enhancement of ECL intensity of Ru(bpy)2+3 in the presence of chlorpromazine hydrochloride，a new ECL method was established for the determination of chlorpromazine hydrochloride at the glassy carbon electrode modified with composite film of graphene and nafion．Under the optimal experimental conditions，the relative ECL intensity had a good linear relationship with concentration of chlorpromazine hydrochloride in the range of 8.0×10-7 -1.2×10-4 mol/L (r=0.998 8),and the detection limit(S/N=3)was 4.0×10-7 mol/L．The RSD for 4.0×10-6 mol/L chlorpromazine hydrochloride (n=11) was 1.4%．The results indicated that the graphene/nafion modified glassy carbon electrode had a good repeatability and sensitivity.The recoveries were in the range of 93%-104%，with RSD (n=5)of 4.1%.The proposed method was applied in the analysis of chlorpromazine hydrochloride tablet with satisfactory results．