A method regarding determination of ethoxyquin residue in fruits was presented by liquid chromatography with inhibited oxidation reactionAnother antioxidant was added in order to inhibit the oxidation reaction of ethoxyquin.In this experiment，the samples were added with vitamin C,homogenized,then extracted with hexane,concentrated to dryness and redissolved in acetonitrile.The target compound was separated on a C18 column using acetonitrile-water as mobile phase,and detected by HPLC.The quantitation limits for ethoxyquin in apple and pear were both 0.05 mg/kg.The spiked recoveries were in the range of 79.4%-108% with relative standard deviations of 3.8%-9.3%.The developed method was suitable for the determination of ethoxyquin in apple and pear samples.