A new method for the determination of norepinephrine（NE）was established with the disposable screen printed electrode（SPE）modified with the multiwalled carbon nanotubes and ZnO nanocomposites（MWNTs-ZnO）using screen printing technology.A sensitive response to NE was obtained on the MWNTs-ZnO SPE at the potentail of 0.28 V.Square wave voltammetric（SWV）response of NE showed that the oxidation peak current of NE at MWNTs-ZnO SPE was linear with its concentration in the range of 0.75-50 μmol/L.The linear regression range was 0.75-50 μmol/L（r2=0.999 3），and the detection limit（S/N=3）was 0.3 μmol/L.This method was simple，rapid and sensitive，and could be used to monitor NE in a large batch of clinical samples.