A comprehensive analytical method based on ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry（UPLC-Q-TOF-MS） was developed for the rapid screening of 18 coumarin compounds（e.g.dihydrocoumarin,7-hydroxycoumarin,6-methoxy-7-hydroxycoumarin,6,7-dimethoxycoumarin,coumarin,7-methoxycoumarin,4-methyl-7-hydroxycoumarin,psoralen,8-methoxypsoralen,7-methylcoumarin,isopsoralen,5-methoxypsoralen,4-methyl-7-ethoxycoumarin,imperatorin,2′,4,8-trimethylpsoralen,8-hydroxypsoralen,isoimperatorin and cyclocumarol） in cosmetics.Various cosmetic samples,including cream,lotion,shampoo,powder and lipstick,were extracted under ultrasonication.The extract was centrifuged,and the upper solution was concentrated with rotary evaporator.The reconstructed solution was then cleaned up with Oasis HLB solid phase extraction cartridge.The screening analysis was carried out by atmospheric chemical ionization-quadrupole-time-of-flight mass spectrometry after the chromatographic separation on a Waters ACQUITY UPLC BEH C18（150 mm×2.1 mm,1.7 μm） column within 10 min.The limits of quantitation（LOQs） for 18 coumarin compounds ranged from 10 μg/kg to 60 μg/kg.The mean recoveries at three spiked levels ranged from 85.2% to 95.1%,with relative standard deviations of 3.2%-8.6%.The method is accurate,rapid and sensitive,and can provide a reliable and effective technique for the high-throughput screening of cosmetics.