A supercritical fluid chromatographic(SFC) method was developed for the determination of tocopherols and α-tocopheryl acetate in cosmetics.Different types of samples were sequentialy dispersed and extracted with acetonitrile water solution-hexane based on matix types.The chromatographic separation was conducted with a XBridge(Viridis@BEH,250 mm×4.6 mm,5 μm) by gradient elution using CO2 as mobile phase and 2-propanol∶hexane(1∶1) as modifier.The detection was performed with a photodiode-array(PDA) detector.The extraction procedures and chromatographic conditions were optimized.The results showed that the limits of quantitation(LOQ,S/N=10) were 50 mg/kg for four tocopherols and 25 mg/kg for α-tocopheryl acetate.The average recoveries ranged from 81.3% to 109.5% with relative standard deviations(RSDs) not more than 12.8%.The method is simple,rapid and accurate,and is suitable for the determination of four tocopherols and α-tocopheryl acetate in cosmetics.