A method was developed for the determination 16 perfluorinated compounds(PFCs) in egg by high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) combined with dispersive solid phase extraction.The samples were extracted with acetonitrile in an ultrasonic bath at 40 ℃.The extract was concentrated with N2, purified with graphitized carbon black（GCB）,and analysed by HPLC-MS/MS.The calibration curves of 16 PFCs were linear in the concentration range of 0.50 -10.0 μg/L with correlation coefficients(r) of 0.996 2-0.999 9.The limits of detection for 16 PFCs were between 0.001 μg/kg and 0.093 μg/kg,and the limits of quantitation were between 0.003 μg/kg and 0.310 μg/kg.The mean recoveries of 16 PFCs at spiked levels of 0.5,1.0,2.0 μg/kg were in the range of 79%-125% with relative standard deviations(RSDs,n=6) of 0.26%-14%.The method was suitable for the identification and quantification of 16 perfluorinated compounds in egg due to its advantages of simplicity,accuracy and high sensitivity.