Sample pretreatment is one of the bottlenecks of microfluidic chip.In recent years,monolithic material has been developed as a new chromatographic packing in the field of chromatography.It has been employed in microfluidic chip because of its advantages of uniform structure,fast mass transfer,good permeability,and simple preparation process.This review summarizes recent developments of the application of monolithic column in microfluidic chip.80 references are cited.