As the high resolution and wide mass measurement range characteristics of a time-of-flight mass spectrometer,a high precision and wide range data acquisition system was designed in this paper.The system completed the amplification,discrimination and level conversion for the front end signal.A high precision time interval measuring chip TDC-GPX was used to measure the pulses’ time interval.A field programmable gate array（FPGA） realized the sequential control.A Universal Serial Bus（USB 2.0） interfaced with a computer.The host computer’s controlment and high-speed data transmission were realized with the time division multiplexing technology.Testing results showed that the single-shot precision is less than 100 ps,the range of measurement time is beyond of 500 μs and the number of measurement channels could be up to 8.