In this paper,a glucose oxidase CdTe quantum dots modified carbon paste electrode(GOD/CdTe/CPE)was prepared by the synthesis of CdTe quantum dots(QDs) to fabricate modified material and fixed the glucose oxidase(GOD) at the surface of the water-soluble CdTe quantum dots,and achieved the direct electrochemistry of GOD at the electrode surface.QDs CdTe can effectively accelerate the direct electron transfer of GOD with the electrode surface,and the electron transfer efficiency was about 8 times more than that in the absence of QDs CdTe.The electron transfer rate constant K was 0.14 s-1 and transfer coefficient was 0.60.The average amount of coverage(Γ) of GOD on the surface of GOD/CdTe/CPE was 7.9×10-8 mol/cm2.As a third generation glucose biosensor,GOD/CdTe/CPE was successfully applied in the detection of glucose concentration.The calibration curve was linear in the range of 0.050-0.32 mmol/L and the detection limit was 0.020 mmol/L.GOD/CdTe/CPE had the advantages of simple preparation,strong stability,excellent selectivity and reproducibility,and fast response.