Microfluidic chip is a kind of technology manipulating fluids in micrometer scale with advantages of flexible integration of variety of cell technology,reducing sample consumption and etc.Raman spectroscopy is an important spectroscopic technique used widely in the fields of chemical,physical and biological sciences,and many other disciplines.Moreover,based on the surface of silver or gold nanoparticles,the enhanced Raman（SERS） technique has very high sensitivity that could be easily used for monitoring environmental pollutants and biological analysis of samples.This paper mainly summarizes the research progress of microfluidic chip in the field of surface-enhanced Raman spectra,including nanoparticle synthesis,chip design and common sensor types,and introduces its applications in life sciences and environmental monitoring,which reveals its broad application prospects.