In this paper,cefepime was found to enhance the chemiluminescence(CL)of the luminol-potassium ferricyanide reaction system in alkaline condition.According to this fact,a flow injection chemiluminescence enhencement method for the determination of cefepime was developed.Under the optimum conditions,the linear range for cefepime was 3.0×10-6-4.0×10-5 g/mL,and the limit of detection was 2.8×10-6 g/mL.The relative standard deviation(RSD,n=11) was 1.5%for the determination of 2.0×10-5 g/mL cefepime.The method was applied in the determination of cefepime injection with satisfactory results.