The volatile compounds in sesame oil were analyzed by headspace gas chromatography-mass spectrometry(GC-MS) with calibrated lineshape isotope profile search(CLIPs) function intergrated in MassWorksTMsoftware.71 kinds of components including pyrazines,pyrroles,pyridines,thiazoles,thiophenes,indoles,oxazoles,furans,aldehydes and phenols,etc.could be identified,which account for 90.2% of the total normalized peak areas.Among them,aldehydes,phenols,pyrazines and furans account for 37.4%,20.1%,10.0%and 6.7%,respectively.They were principal contributors of sesame oil flavor components.The application of CLIPs can provide the accurate molecular weight of compounds and an important basis for the low-resolution quadrupole mass spectrometer to identify the elemental composition and the structure of compound.The study provided a new technical means for the component analysis of sesame oils.