Fe3O4@SiO2-NH2 magnetic nanoparticles composites were successfully synthesized by three-step method，and used as adsorbents for the extraction and analysis of seven typical perfluorinated compounds（PFCs） in water solution. In combination with ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometry（UPLC-MS/MS），a method to determine seven typical perfluorinated compounds in water was established. The synthesized material was characterized by TEM，SEM and FT-IR. The influencing factors including desorption solvent，volume of desorption solvent，desorption time，extraction time and pH value of solution were investigated. The result showed that amino was successfully modified on the surface of Fe3O4@SiO2 magnetic nanoparticles. Fe3O4@SiO2-NH2 magnetic nanoparticles composites exhibited a good extraction effect on the target perfluorinated compounds，and the optimum extraction efficiency was achieved as follows： extraction time： 20min，desorption solvent: 3mL×4 0.28% ammonia methanol solution，desorption time： 5min，and pH value： 5.0.Under the optimum conditions，the calibration curves of seven perfluorinated compounds were linear in the range of 1-500ng/L,with limits of detection of 0.2-0.5ng/L.The method was applied in the detection of target perfluorinated compounds in real water with spiked recoveries no less than 82.0%.