A rapid method was developed for the determnation of 4 thiurams vulcanization accelerators,tetrabenzyl thiuram disulfide(TBZTD),dimethyldiphenylthiuram disulfide(TMD),thiram D12 and dicyclopentamethylenethiuram disulfide(DPTD) in rubber products by ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).Rubber samples were diluted in methanol and extracted by ultrasonic.After centrifugation and filtration,the target compounds were separated on a reversed phase C18 column with a mixture of methanol and water as mobile phase,analyzed by UPLC-MS/MS and quantified by the external standard method.Separation of the target substances in different chromatographic conditions was investigated,and effects of different extraction solvents on extraction effienciency were investigated.Under the optimal conditions,the calibration curves for TMD,thiram D12,TBZTD and DPTD were in good linearity in the ranges of 0.002-1.000,0.002-1.000,0.100-10.000, 0.020-10.000 mg/L,respectively,with limits of quantitation of 0.001 0,0.001 2,0.100 0,0.020 0 mg/L,respectively.Recovery tests were made by the addition of standards to blank sample at different concentrations,and the recoveries were in the range of 82.7%-98.8% with relative standard deviations(RSDs,n=5) of 4.6%-7.0%.The method is simple,rapid and sensitive,and could meet the requirements for detection of TBZTD,TMD,Thiram D12 and DPTD in rubber products.