A rapid method was developed for the quantitative analysis of perfluorinated compounds（PFCs) including perfluorooctane sulfonic acid（PFOS）,perfluorooctanoic acid（PFOA）,perfluoroundecanoic acid（PFUnA）,perfluorododecanoic acid（PFDoA）,perfluorotridecanoic acid（PFTrDA）,perfluorotetradecanoic acid（PFTA） in coastal and estuarine seawater by solid phase extraction（SPE） enrichment with ultra high performance liquid chromatography tandem electrospray ionization mass spectrometry（UHPLC-MS/MS）.Seawater sample was enriched and purified through a 500 mg C18 SPE cartridge at 5.0 mL/min,eluted with 15 mL mixed solvent of methanol and ethyl acetate（4∶1）, and finally concentrated into 1.0 mL with an automated de-solvent device.Target analytes were separated on a Kinetex XB-C18 column using methanol（containing 5.0 mmol/L NH4COOH-water（containing 5.0 mmol/L NH4COOH） as mobile phase.The negative electrospray ionization（ESI-） and multiple reaction monitoring mode（MRM） were utilized.An internal standard calibration method was chosen for the quantitative analysis.The calibration curves of PFCs were linear in the range of 0.5-50.0 μg/L with correlation coefficients more than 0.999 0.The limits of quantitation（LOQs,S/N=10） were between 0.5 ng/L and 1.5 ng/L.The recoveries of 6 PFCs at three spiked levels（2.0,5.0,10.0 ng/L） were in the range of 80.1%-117.4%,and relative standard deviations（RSDs） were 8.2%-12.1% at spiked level of 2.0 ng/L.