A method was established to determine simultaneously the residues of 21 harmful organic solvents in leather and leather products by gas chromatography-mass spectrometry in selected ion monitoring mode（GC-MS/SIM）.Residual harmful organic solvents in leather and leather products were ultrasonically extracted at 45℃,using ethyl acetate as extraction solvent.The extracts were purified with solid-phase extraction（SPE） columns,and then analyzed by gas chromatography-mass spectrometry in selected ion monitoring mode（GC-MS/SIM）.The content of each analyte was calibrated by the external standard method.At the condition of signal to niose（S/N） of ten,the limits of quantitation（LOQs） were 50μg/kg for ethylene glycol dibutyl ether（EGDBE）,triethylene glycol dimethyl ether（TEGDME）,diethylene glycol butyl ether（DEGBE） and triethylene glycol ethyl ether（TEGEE）,150μg/kg for N-methylformamide（MF） and N-methylacetamide（MA）,300μg/kg for formamide,and 100μg/kg for all the other fourteen compounds.The spiked average recoveries varied from 82.1% to 94.9% at three spiked levels with relative standard deviations（RSD） of 1.6%-4.8%.The proposed method was simple,rapid,accurate and sensitive,and was suitable for the determination of residual harmful organic solvents in leather and leather products.