A DART coupled with Orbitrap mass spectrometric method was developed for the qualitative and quantitative analyses of scutellaria radix.The component was identified by comparing with standard component and the report of relative researches as well as the full scan spectra and secondary spectra.In quantitative analysis,the Full MS-SIM and Targeted-MS2 mode was applied to obtain the mass spectrum,extract ion chromatography based on the parents ion and the product ion of baicalein(m/z 271.06→123.01) and wogonin(m/z 285.07→270.05) were used for quantitative analysis in the Targeted-MS2 mode.The signals of baicalein,wogonin,SkullcapflavonⅡ and other components were observed in the mass spectra of scutellaria radix.The linear ranges of baicalein and wogonin were 49.7-447.3 ng(r2=0.995) and 50.0-350 ng(r2=0.995),respectively.Their average recoveries were 87.0% and 66.0%,respectively.This method is suitable for the rapid analysis of scutellaria radix and other traditional Chinese herbal medicines.