Hydrophilic molecularly imprinted polymers(MIPs)were synthesized via the bulk polymerization with α-1-allyl-2-N-acetyl glucosamine as novel water miscible functional monomer and N,N′-methylenebisacrylamide as cross-linker,which introduce the abundance of hydrophilic groups into MIPs.The photographs of the dispersion properties and water contact angles demonstrated that MIPs presented an excellent hydrophilicity.The binding experiments indicated that MIPs exhibited an excellent imprinting effect and a high selectivity to gastrodin.Under the optimum molecular imprinted solid phase extraction(SPE) conditions,MIPs could be used as an adsorbent phase to enrich gastrodin from gastrodia elata.The method showed excellent recoveries(90.4%-97.1%)and precision(3.3%-5.2%,n=5).Based on the new type of hydrophilic functional monomer, a molecularly imprinted solid phase extraction sample pretreatment method for glycosidic substance was established.