A method was developed for the determination and conformation of 21 illegal chemical drugs in antihypertension traditional Chinese medicines and health care foods by HPLC-DAD and LC-MS/MS with sub-3 μm particle column.The samples were extracted with methanol-acetonitrile(5∶5,by volume),then separated on an Agilent Poroshell 120 phenyl-Hexyl(100 mm×4.6 mm,2.7 μm) by gradient elution with methanol-acetonitrile(2∶1,by volume)- formic acid water solution(pH 2.5±0.1) as mobile phase,detected with DAD in wavelength range of 200-400 nm.Quantification analysis were performed by the external standard method.The positive samples were further identified and verified by LC-MS/MS.The results indicated that 21 analytes were separated completely in 17 min.The detection limits of 21 target compounds ranged from 0.03 mg/g to 0.50 mg/g.The average recoveries at three spiked levels ranged from 82.0% to 109.0%.The method was applied in the analysis of 107 batches of samples from online shopping,among which 45 batches were added with the chemicals with a positive rate of 42.1%.The method was accurate,rapid and sensitive,and was suitable for the determination of illegally added chemical drugs in traditional Chinese medicine and healthy food of antihypertension.