An HPLC method was established for the chiral separation of cinacalcet raw material,1-(1-naphthyl)-ethylamine(compound-1) and intermediate of cinacalcet(compound 2),by using self made 1 naphthalene vancomycin as chiral stationary phase(Na-VAN CSP),and D-tartaric acid(D-Tar)，L-tartaric acid diethyl ester(L-TADE) and D-tartaric acid diethyl ester(D-TADE) as chiral mobile phase additives(CMPA),respectively.The influences of alcohol modifiers and CMPA types were studied.The mechanism of enantioseparation was also discussed.On Na-VAN CSP,compound 1 and 2 got certain degree of enantioseparation with different CMPA under normal phase conditions.When D-TADE was used as CMPA,the optimal enantioseparation for both compound 1 and 2 was obtained.The results showed that the size of alcohol modifier and the three dimensional configuration of CMPA played an important role in the enantioseparation.