A method for the rapid determination of 21 adulterants in anti rheumatic Chinese patent drugs or dietary supplements was established by HPLC using sub 3 μm fused core silica particles columns.The samples were extracted with 1% acetic acid methanol,and separated on the fused core column ACCHROM C18 100A (4.6 mm×100 mm,particle size 2.8 μm) column by gradient elution with a water solution of phosphoric acid (pH 3.0)-methanol-acetonitrile as mobile phase at a flow rate of 1.0 mL/min.The detection wavelengths were set at 230 nm and the column temperature was set at 35 ℃.Under the conditions,21 compounds could be separated within 20 min,and the calibration curve of naproxen showed a good linearity in the range of 1.5-30 μg/mL while those of the other 20 compounds were in the range of 5-100 μg/mL，and the detection limits(S/N=3) were 0.8 mg/kg for naproxen and 2.0 mg/kg for other compounds.The recoveries were between 91.0% and 1091%.The method was applied in the detection of real samples,and 18 positive samples were found.The samples were further confirmed by HPLC-MS/MS.The results indicated that this method was rapid and accurate,and could be used for the rapid determination of illegal adulteration in anti-rheumatic Chinese patent drugs or dietary supplements,which indicates its extensive application prospect.