The aim of this paper was to understand the concentrations of perfluorinated compounds(PFCs) and common metal elements in children’s blood and provide data for the assessment of children’s health. The samples were extracted by protein precipitation, and then detected by high liquid chromatography-electrospray-mass spectrometry(HPLC-MS/MS). Meanwhile, the samples were digested with graphite automatic instrument, and then calcium(Ca), magnesium(Mg), iron(Fe), zinc(Zn), copper(Cu) and manganese(Mn) in samples were determined by inductively coupled plasma-mass spectrometry(ICP-MS).The PFCs in children’s blood were widely detected. The frequencies and concentrations of perfluorooctane sulfonate(PFOS) and perfluorooctanoic acid(PFOA) were the highest, whereas some other PFCs with higher concentrations were found in some blood samples. A negative correlation was found between the concentrations of PFCs and the children’s age. There was no gender difference in the concentrations of PFCs except perfluorobutane sulfonate. The concentrations of Ca, Mg, Fe, Zn, Cu and Mn were in normal range. The PFCs in children’s blood were widely determined. Concerns regarding children exposure to PFCs are needed. Focus should be paid not only on PFOS and PFOA, but also on other PFCs in the future monitoring.