A high throughput method based on gas chromatography-triple quadrupole mass spectrometry(GC-MS/MS) was established for the determination of 25 kinds of organophosphate esters(OPEs) and phthalate esters(PAEs) compounds in baked foods and plastic packing materials.For baked foods,the samples were ultrasonically extracted with acetonitrile:acetone(8∶2，by volume),and then purified by QuEChERS with 50mg C18 and 50mg PSA.For plastic packaging materials,GC-MS/MS analysis was performed directly after dichloromethane-methanol extraction.All the samples were separated with a DB-5ms chromatographic column,and detected in selected reaction monitoring(SRM) mode. The correlation coefficients for 25 compounds were not less than 0.9975,and the method detection limits were in the range of 10-500μg/kg. The average recoveries(n=6) ranged from 80.2%-119.6% with the RSDs of 1.5%-9.4%.The developed method, with the advantages of easy operation, satisfactory purification effect and favorable matrix effect elimination capacity, was suitable for the determination of OPEs and PAEs in different kinds of baked foods and plastic packing materials.