An analytical method was developed for the determination of 30 anti-impotence compounds illegally adulterated in health products by ultra high performance liquid chromatography-triple quadrupole mass spectrometry(UHPLC-MS/MS) with a Waters CORTECS T3(100 mm×2.1 mm，2.7 μm) column using 0.1%(by volume) fomic acid aqueous solution-acetonitrile containing 0.1%(by volume) formic acid as mobile phases by gradient elution.The compounds were detected with electrospray ion source in positive mode under multiple reaction monitoring(MRM) mode.The calibration curves for 30 targeted compounds were linear in the mass concentration range of 10-200 μg/L with correlation coefficients more than 0.99.The mean recoveries at spiked levels of 0.1,0.2，1.0 mg/kg were in the range of 62.8%-135.2%,with RSDs(n=6) not more than 14%.The limits of detection(LODs) and the limits of quantitation(LOQs) were 0.05 mg/kg and 0.1 mg/kg,respectively.The established method is accurate and simple,and could be used as a reference for the national standard.