In this paper,a GC-MS/MS method was established for the determination of the residue and migration amounts of six preservatives.The migration regularity of six preservatives from sample to simulated saliva and sweat was studied,and the migration rates at different times were calculated through building a self-made migration device to simulate the actual exposure scenarios.The results showed that the migration amount of preservatives gradually increased with time in range of 2 min to 96 h,and finally reached the migration equilibrium.The migration rates in saliva and sweat were in the ranges of 2.1%-61.7% and 2.2%-86.4%,respectively.It was worth noting that when the sample was in contact with the simulated solution for only 2 min,the analytes could be detected,and the migration rates in saliva and sweat were 2.1%-4.2% and 2.2%-3.3%,respectively.Some commercial samples were detected to contain 2,4-DCP and 2,4,6-TCP.Due to the characteristics of children’s daily short duration contacting with the sample,two positive samples were selected for the determination of their migration amounts and migration rates in 2-30 min.