In this paper,the electrochemical behavior of furosemide(FUR) at 3-anminopro-pyltriethoxsilane(APTS) and graphene(RGO) modified carbon paste electrode(APTS-RGO/CPE) was studied.The experimental results indicated that compared with CPE,APTS-RGO/CPE showed a good promotion towards FUR electrochemical oxidation,and the oxidation peak current increased significantly.Cyclic voltammetry(CV) and chronoamperometry(CA) were used to determine the reaction kinetics parameters of FUR on the APTS-RGO/CPE electrode.The relationship between FUR oxidation peak current and its concentration was evaluated by differential pulse voltammetry(DPV).The oxidation peak current of FUR and its concentration has a good linear relationship in the concentration range of 1.3-330 mg/L with the limit of detection(S/N=3) of 1.1×10-2 mg/L.The proposed method was successfully applied in the determination of commercial tablet samples,with their relative standard deviations of 0.4%-4.4%and recoveries of 98.5%-99.7%.The results were in accord with the requirement of quantitative detection.