A high performance liquid chromatography-tandem mass spectarometry was established for the determination on migration amounts of bisphenol A,bisphenol F and bisphenol S in food contact materials.Bisphenol A,bisphenol F and bisphenol S were transfered into the food simulants in the sample contacted at a certain temperature and time.The separation was performed using a C18 chromatographic column with methanol-ammonia as mobile phase.Under the electrospray ionization(ESI)mode,bisphenol A,bisphenol F and bisphenol S were detected in a multiple-reaction monitoring mode(MRM),and quantified by the external standard method.The method indicated a perfect performance in chromatographic separation.The calibration curves of bisphenol A and bisphenol F were linear in the range of 1-50 μg/L,while the calibration curve of bisphenol S was linear in the range of 0.1-50 μg/L.The limits of detection were 0.3 μg/L for bisphenol A and bisphenol F,and 0.05 μg/L for bisphenol S.The recoveries ranged from 83.6%to 102.6%,with relative standard deviations(RSDs) of 3.5%-8.9%.This method was rapid,accurate,precise and convenient,and was appropriate for the determination of bisphenol A,bisphenol F and bisphenol S in food contact materials.