A high performance liquid chromatography（HPLC）coupled with inductively coupled plasma mass spectrometric（ICP-MS） method was developed for the determination of six kinds of inorganic elements，including Cr（Ⅵ），Cr（Ⅲ），As（Ⅲ），As（Ⅴ），Se（Ⅳ）and Se（Ⅵ）in juice drinks.After ultrasonic extraction，the samples were added with EDTA solution，separated with a C8 column using 0.1 mmol/L tetrabutyl ammonium hydroxide，0.1 mmol/L ammonium acetate and 10% methanol as mobile phases，and then determined by ICP-MS.The DRC mode was used to eliminate the interference and ensure the accuracy of determination.The detection limits for the 6 element speciations were 0.34，0.20，0.50，0.40，0.82 and 0.90 μg/L，respectively.The recoveries for the analytes were between 79.5% and 112% with the relative standard deviations（RSDs）（n=6）less than 5.0%.Using this method，six inorganic speciations were undetected in apple juice，while Cr（Ⅲ）and Se（Ⅳ）were detected in blueberry juice with contents of 0.007 mg/kg and 0.015 mg/kg，respectively,and 3 element speciations were detected in cereals juice with contents of 0.008-0.034 mg/kg.